We are a leader in the interpretation of high-throughput biomedical data including variant interpretation, pathway analysis, disease subtype discovery and integration of multiple data types. Currently, 9 of the top 10 pharma companies rely on Advaita’s state-of-the-art algorithms to solve complex problems. Advaita provides a suite of advanced analysis software to more that 13,000 registered users worldwide: iPathwayGuide, for functional interpretation of genes and proteins; iVariantGuide, for genetic variant analysis; and iBioGuide, a search engine revealing connections between genes, pathways, SNPs, drugs, and more.
Our mission is to bridge the gap between the ability to collect and interpret biological data.
Advaita Bioinformatics develops bioinformatics data analysis tools with capabilities to integrate multi-‘omic’ data from a systems biology perspective. Our proprietary computational method, Impact Analysis, considers the type, function, position and interaction between genes in a pathway as opposed to other approaches that consider genes to be independent.
Through our $2.2 million NIH STTR Phase II award, we have developed a software platform called Pathway-Guide for the analysis of data from high-throughput microarray and next-generation sequencing experiments. Our next generation product, iPathwayGuide, is a web-based pathway analysis application based on our Impact Analysis method. We are the only company in the industry that includes other crucial factors about the genes in addition to classical statistics. iPathwayGuide includes unique capabilities such modeling SNPs, miRNAs and drugs directly on the pathways and predicting miRNA potentially regulating gene expression in your samples based only on mRNA data. Our vision is to create a platform for multi-omic integration and analysis from a systems biology level.
Advaita Bioinformatics is also working on developing innovative tools for subtyping of diseases and patients. These tools address the classic “responder” vs. “non-responder” problem facing 50% of drugs that reach Phase 3 clinical trials. With our technology, we can identify truly homogeneous populations and the mechanisms that distinguish them from other populations.
Our vision is to:
reduce healthcare costs by facilitating efficient decision making for drug development
advance personalized medicine by identifying patients with similar underlying disease mechanisms
empower researchers to make breakthrough discoveries by analyzing multi-omic data from a systems biology perspective
Our Team Leaders
The Advaita Bioinformatics team is built from a broad range of expertise and backgrounds. We pride ourselves in having the most capable team to deliver the best tools and knowledge for our customers.
Dr. Draghici is a Professor in the Department of Computer Science, and the head of the Intelligent Systems and Bioinformatics Laboratory at Wayne State University. He also holds a joint appointment in the Department Obstetrics and Gynecology and is an Associate Dean in Wayne State University’s College of Engineering. Dr. Draghici is a senior member of IEEE, and an editor of IEEE/ACM Transactions on Computational Biology and Bioinformatics, Protocols in Bioinformatics, Discoveries Journals, Journal of Biomedicine and Biotechnology, and International Journal of Functional Informatics and Personalized Medicine. His publications include two books (”Data Analysis Tools for DNA Microarrays and Statistics” and ”Data Analysis for Microarrays using R”), 8 book chapters, and over 150 peer-reviewed journal and conference publications which gathered over 12,000 citations to date.
Dr. McEachin joins Advaita Bioinformatics in the dual role of Senior Scientist and COO. His efforts are devoted to leadership of the team of Advaita professionals, continued development of Advaita products, customer service, and day-to-day management of operations. He has more than 25 years of data analysis experience, including 15 years in bioinformatics and 10 years in operations research. Prior to joining Advaita, Dr. McEachin served for 4 years as Managing Director of the University of Michigan’s bioinformatics core. His education includes a PhD in Human Genetics and an MS in Biostatistics, both from the University of Michigan. In addition to his work at Advaita, Dr. McEachin serves as an Adjunct Assistant Professor of Biostatistics at the University of Michigan. He also volunteers for the Galactosemia Foundation and Buddy-to-Buddy.
Dr. Vanciu’s research interests are in system security, software maintenance and program comprehension. As part of his Ph.D. work at Wayne State University, he designed and developed an approach for finding security vulnerabilities in applications written in Java-like code, with an emphasis on Android applications. The approach focuses on finding vulnerabilities that are architectural flaws, such as misuse of cryptography, which are more difficult to find by existing fully automated approaches that identify only localized coding bugs among which are hard-coded password and unsafe system calls. Since he joined the Advaita team, Dr. Vanciu applies his expertise to improve the development process, lower the cost of code maintenance, as well as ensure and improve the quality of web-applications that support the analysis of gene-expression data. Such web-applications need to be secure to ensure data confidentiality, and highly flexible in order to quickly and safely adapt to the continuous enhancements required by our customers.
As Chief Science Officer, Dr. Ziraldo leads product development and technical support for Advaita’s state-of-the-art bioinformatics platform. She is passionate about producing software that puts life scientists in the driver’s seat of their data analysis, enabling them to leverage the domain expertise that they uniquely possess instead of relying solely on bioinformaticians. Before joining Advaita, Dr. Ziraldo completed a postdoctoral fellowship at the University of Michigan, working collaboratively between the departments of Chemical Engineering and Microbiology & Immunology. She received her PhD in Computational Biology in 2013 from a joint program between Carnegie Mellon and the University of Pittsburgh.
Director of Software Development
AdvaitaBio is searching for an individual with at least 5 years of experience in the development of web applications. The successful candidate will lead a growing team of developers with a vision for developing an intuitive, easy-to-use SaaS platform for biomedical researchers.
Advaita is a small but fast-growing company that uses artificial intelligence and data science approaches to enable breakthrough discoveries in biomedical research, medicine and drug development. We are changing the way research in medicine and drug development is done. Our customers are world-renowned scientists working on game-changing problems in life sciences. Our products help them understand diseases, improve patient outcomes and develop new treatments.
Responsibilities include leading the team designing and developing user-friendly bioinformatics tools for the analysis and visualization of biomedical data. The successful candidate will have software architecture design skills and will have, or be interested to develop, leadership and management skills. Previous bioinformatics experience is helpful but not required.
We prefer candidates who are willing to expand their expertise but already have several years of experience with the following technologies:
- Bootstrap 3 or Angular Material, and CSS stylesheets
- RESTful APIs
- GIT for code versioning
- Maven, Spring-boot, Spring Web
- Docker, Java, Spring-Framework, R and relational databases such as PostgreSQL
Other helpful skills include:
- Using security protocols such as OAuth 2.0
- Using agile development processes such as SCRUM
- Data engineering and visualization of biological data using tools such as Cytoscape.js
- Problem solving and data engineering using R or Python libraries for data science (e.g., Bioconductor, NumPy, Pandas)
- Integrate products using Amazon Web Services such as notification services (SNS), and queue services (SQS), and EC2 Container Service (ECS)
- Continuous integration tools
- UX design principles and applications
Advaita offers benefits including health, vision, and dental insurance, a retirement plan, and can also sponsor work visa and green card applicants. Stock options in an extremely promising company are an important component of the compensation package. Come and have a rewarding software development career while helping to make the world a better place!
Advaita’s goal is to enable meaningful multi-omic analysis for researchers and industry users. We collaborate with organizations with similar goals, opportunities, and complementary capabilities.