Covid19 Forum Repurposing existing drugs Drugs approved for human use with reported anti-COVID-19 activity.

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  • drbarry
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    Re: drugs that might be repurposed for the treatment of COVID-19. I have found three drugs so far approved for human use previously that seem to show some promise and supported by the scientific literature.
    Niclosamide
    see Jimin Xu et al ACS Infectious Diseases March 3rd, 2020
    Niclosamide’s mode of action is complex regulating multiple signalling pathways. I don’t know much about it but the paper looks pretty solid to me.
    Leflunomide/Teriflunomide
    see Rui Xiong et al bioRxiv (unpublished)
    preprint requests to Dr. Ke Xu email: xuke03@whu.edu.cn

    Both Leflunomide and Teriflunomide target a mitochondrial enzyme (DHODH) that catalyzes a critical step in pyrimidine nucleotide biosynthesis. As the viral genome is a single-stranded RNA with a high uracil content inhibition of DHODH inhibits viral replication. Side effects include immunosuppression that is ameliorated by coadministration of deoxycytidine.
    I am not a virologist but have been working in the area of pyrimidine metabolism for nearly 40 years now and these two drugs look pretty good to me. cheers Barry Barclay

    Barry J Barclay PhD
    1 Elmwood Pl
    St Albert AB
    Canada T8N 5K4

    Email: drbarry46@gmail.com
    Tel/Txt: (780) 935-4267

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