iPathwayGuide supports directly human, mouse and rat. For other organisms, you need to first map your genes to orthologs. Many of our users have done this very successfully.
Here is an example in which iPathwayGuide was used to make important discoveries involving mackerel and sardines:

Transcriptomic analysis of short-term 17α-ethynylestradiol exposure in two Californian sentinel fish species sardine (Sardinops sagax) and mackerel (Scomber japonicus).

When you complete and publish your research, please share it with us. We will be happy to make your research more visible by sharing it with our users.