All six tabs draw on the same gene set and interaction database. Four are pure layout changes with no filtering:
- Subnetworks — groups genes into connected components to show whether the DE list forms coherent modules.
- Hub Genes — positions the most-connected genes at the center and isolated genes on the outer ring.
- Interactions — uses a circular layout ordered clockwise by absolute log2 fold change, where chord length reflects how similarly two interacting genes are changing.
- Regulators — emphasizes directed regulator→target relationships.
Two tabs apply a filter:
- Mechanisms — keeps the minimum set of interactions needed to connect the genes, selecting edges by evidence score and directional coherence. This is the most defensible view for a mechanism claim, since every edge shown survived an evidence filter.
- Gatekeepers — isolates bottleneck genes: the only route between otherwise separate parts of the network. Useful for identifying which single gene, if removed, would disconnect the response.